ov nc (MedChemExpress)
Structured Review

Ov Nc, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ov+nc/pmc11543847-103-8-10?v=MedChemExpress
Average 92 stars, based on 2 article reviews
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1) Product Images from "Elevated ITGA3 expression serves as a novel prognostic biomarker and regulates tumor progression in cervical cancer"
Article Title: Elevated ITGA3 expression serves as a novel prognostic biomarker and regulates tumor progression in cervical cancer
Journal: Scientific Reports
doi: 10.1038/s41598-024-75770-x
Figure Legend Snippet: The impact of ITGA3 on t apoptosis rates in cervical cancer cell. ( A ) The immunofluorescence images of ITGA3 in human cells from the HPA database. Blue: cell nucleus, red: microtubules, and green: ITGA3. ( B ) The expression of ITGA3 in various cervical cancer cell lines in CCLE database. ( C and D ) WB analysis of ITGA3 in cells transfected with ov-NC, si-NC, ov-ITGA3 and si-ITGA3 lentivirus. ( E ) PCR analysis of ITGA3 in ov-NC, si-NC, ov-ITGA3 and si-ITGA3 groups. ( F ) Cell viability in ov-NC, si-NC, ov-ITGA3 and si-ITGA3 groups detected by CCK-8 assay. p represents the comparison with the si-NC group, while # represents the comparison with the ov-NC group. ** p < 0.01, * p < 0.05. ## p < 0.01, # p < 0.05 ns means no statistical difference. (G and H) Flow cytometry assay displayed the apoptosis rates in four groups and bar charts are used for visualization. (K-M) WB analysis of Bax and Bcl-2 protein expression in two groups. *** p < 0.001, ** p < 0.01, * p < 0.05. ns means no statistical difference.
Techniques Used: Immunofluorescence, Expressing, Transfection, CCK-8 Assay, Comparison, Flow Cytometry
Figure Legend Snippet: Increment of ITGA3 promotes tumor progression in vitro. ( A - D ) wound healing ( A and B ) and transwell assays ( C and D ) were used to detect the ability of cell migration and invasion between ov-NC and ov-ITGA3 groups. ( E - K ) WB analysis of N-cadherin, E-cadherin, vimentin, MMP2 and MMP9 in two groups. ( L - N ) WB analysis of p-I3K and p-Akt in two groups. Data are shown as means ± S.D. * p < 0.05, ** p < 0.01, *** p < 0.001. ns means no statistical difference.
Techniques Used: In Vitro, Migration